Brain Computation Is Organized via Power-of-Two-Based Permutation Logic

The Theory of Connectivity proposes that the origin of intelligence is rooted in a power-of-two-based permutation logic, producing specific-to-general cell-assembly architecture capable of generating specific perceptions and memories, as well as generalized knowledge and flexible actions. Here they show that this power-of-two-based permutation logic is widely used in cortical and subcortical circuits across animal species and is conserved for the processing of a variety of cognitive modalities. The computational logic of modulatory neurons is implemented in the cortex via combining a random-connectivity strategy in superficial layers 2/3 with nonrandom organizations in deep layers 5/6. This simple mathematical logic can account for brain computation across the entire evolutionary spectrum, ranging from the simplest neural networks to the most complex. Read more


Posted on 1 mrt 2017

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EEG-predictors in Major Depression

First EEG-results from the EMBARC study, published in JAMA Psychiatry. Pretreatment Rostral Anterior Cingulate Cortex Theta Activity seems to be associated with Symptom Improvement in Depression. However, the effects seem to be unspecific since they are found in placebo and verum group. The search continues...

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It’s all about timing…

 This report from UC Berkeley highlights age-related decreases in coupling between slow oscillations and sleep spindles during non-REM sleep, correlated with a reduction in the ability of forming new overnight memories.

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Up to date EEG research

A special issue of Biological Psychiatry: Cognitive Neuroscience and Neuroimaging on "High Temporal Resolution Measures of Human Brain Processing" focus on EEG 

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