LSD is in the spotlight again. Recent trials are assessing the effectiveness of LSD as an antidepressant or an adjunctive drug in psychotherapy. However, surprisingly little is known on the effects of LSD on the autonomic nervous system in humans. This study sheds light on the association between LSD-related subjective experiences and autonomic sympathetic and parasympathetic function. Maybe it will be possible to stratify patients according to their electrophysiological profile before allocating them into a LSD treatment.